Fatal acetaminophen poisoning with hepatic microvesicular steatosis in a child after repeated administration of therapeutic doses
نویسندگان
چکیده
منابع مشابه
Severe hepatotoxicity after therapeutic doses of acetaminophen.
BACKGROUND Acetaminophen overdose is a frequent cause of acute liver failure. Controversy exists over the rare association of severe hepatotoxicity or acute liver failure with therapeutic doses of acetaminophen. CASE SUMMARY A 45-year-old white man weighing 85 kg with asymptomatic HIV, hepatitis B virus, and hepatitis C virus (HCV) infection presented with signs of severe hepatotoxicity: aspa...
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N-acetylcysteine (NAC) is a drug used widely and effectively in oral and intravenous forms as a specific antidote for acetaminophen poisoning. In children considering the toxic dose of acetaminophen ingested by the patient and the body weight, the physician prescribes a specific dose of NAC. There is always a risk of iatrogenic overdose of NAC which can cause different mild to...
متن کاملN-Acetylcysteine Overdose After Acetaminophen Poisoning
N-acetylcysteine (NAC) is a drug used widely and effectively in oral and intravenous forms as a specific antidote for acetaminophen poisoning. In children considering the toxic dose of acetaminophen ingested by the patient and the body weight, the physician prescribes a specific dose of NAC. There is always a risk of iatrogenic overdose of NAC which can cause different mild to...
متن کاملLabel-free Evaluation of Hepatic Microvesicular Steatosis with Multimodal Coherent Anti-Stokes Raman Scattering Microscopy
Hepatic microvesicular steatosis is a hallmark of drug-induced hepatotoxicity and early-stage fatty liver disease. Current histopathology techniques are inadequate for the clinical evaluation of hepatic microvesicular steatosis. In this paper, we explore the use of multimodal coherent anti-Stokes Raman scattering (CARS) microscopy for the detection and characterization of hepatic microvesicular...
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ژورنال
عنوان ژورنال: Forensic Science International
سال: 2020
ISSN: 0379-0738
DOI: 10.1016/j.forsciint.2020.110258